Sensory Rejuvenation Protocol:
The Amazing Weekly (6-Day) Protocol to Invigorate Your Inner Ear and over all Energy Reserves.
This protocol can be done in 2-3 days per phase. This article will reference the 2 day protocol or the 2-2-2. On MitoZen.com the products are sold in a 3-3-3 or day day per phase kit.
“Sensory Rejuvenation Protocol” stands for a technique to invigorate your inner ears. This is done through improving and renewing your mitochondria. Mitochondria (Mito) are intracellular powerhouses that produce ATP, the currency of energy in our body. 1/3 of your body weight is made up of the mito within your cells. These little structures sit inside each of your cells, where they convert glucose and oxygen to create all the energy needed to run every aspect of all your cellular functions, including your inner ear. They keep your brain running, your hormones secreting hormones, your heart beating, your lungs absorbing vital air, your immune system functioning to protect you from all the viruses, bacteria, and molds in our environment, your gut absorbing nutrients, your ears working 24/7 and really anything else you can imagine your body would need energy to do anything and everything. You should appreciate your mitochondria and take care of them, but we don’t always get practical ways to do this.
In this article, we will be discussing a protocol founded on science, to care for your mitochondria. Taking care of your mitochondria can potentially make positive changes in your health and longevity…..and your hearing and inner ear health! Studies show mito function can impact the quality and length of your life in almost every way you can consider. A worthwhile effort indeed! We will dig into a few technical subjects such as Autophagy, Mitophagy, Cellular Senescence, and NAD+.
Let’s get into it and make sense of the four-day protocol called “Sensory Rejuvenation Protocol”.
“Sensory Rejuvenation Protocol” is a six-day program where the first two days are focused on NAD+ loading, and the next two days focused on activating Mitophagy, Autophagy, and cleaning up Senescent Cells. This cleaning/ recycling of mitochondria and old, weak zombie cells is done using Senolytics, and a 24 hour fast from lunch to lunch.” The Last 2 days are where your going to activate stem cells for repair and regeneration.
NAD+ Loading Phase – Phase 1
First, let’s discuss why you might want to supplement with NAD+, NAD+ or Nicotinamide Adenine Dinucleotide. NAD+ is a sister to Niacin, which is a vital vitamin that you cannot live without. NAD+ is a critical coenzyme found in every cell in your body, and it’s involved in hundreds of metabolic processes. Maintenance of an optimal NAD+/NADH ratio is essential for mitochondrial function. The maintenance of the mitochondrial NAD+ pool is of crucial importance. From plants to metazoans, an increase in intracellular levels of NAD+ directs cells to make adjustments to ensure survival, including increasing energy production and utilization, boosting cellular repair, and coordinating circadian rhythms. By the time we are middle-aged, levels of NAD+ will have fallen to half of the youthful levels. In recent years, several studies have shown that the treatment of old mice with precursors to NAD+ can greatly improve health. Observed effects include increased insulin sensitivity, a reversal of mitochondrial dysfunction, reduced stem cell senescence, and lifespan extension. 1 Here are a couple of studies on NAD+ and Hearing Loss. Short-term NAD+ supplementation prevents hearing loss in mouse models. Ref 15 Vitamin Supplement with NR a precursor to NAD+ Successfully Prevents Noise-Induced Hearing Loss. Ref 16 Euler-Chelpin, in his 1930 Nobel Prize speech, says, “NAD+ is one of the most widespread and biologically most important activators within the plant and animal world.” 2
NAD+ levels are related to the expression of NF-κB (Tirumurugaan et al., 2008) 6, and low-grade inflammation is a primary driving force of aging. A possibility is that addressing inflammation is the answer to slowing the aging process. Doctors in the know, and scientists in the field, all conclude that molecules that maintain NAD+ levels, will allow people to celebrate many more anniversaries. Inflammation is not just linked to aging but is present and involved in almost all disease processes.
NAD+ levels naturally decline with age, and various stressors can deplete your NAD+ at a more rapid rate. Poor restorative sleep and alcohol use are the top two stressors that deplete NAD+; however, any stressor will drain away NAD+. Anytime you have a higher energy demand, immune activation due to infections stress, mental stress, emotional stress, physical stress, structural stress, electromagnetic (EMF’s) stress, and chemical stress are the main “Stress” categories. We cannot avoid these completely, and so, inevitably, our NAD+ levels will be taxed, creating a need to replace NAD+.
In this article titled “Why NAD+ Declines during Aging: It’s Destroyed,” the author states, ’”NAD+ is required not only for life but for a long life…the decline of NAD+ during aging, with implications for combating age-related diseases.” 4
I don’t advocate ignoring underlying stressors driving inflammation and only supplementing with NAD+, but approaching it from both sides… well, you might be looking at the future of medicine.
Autophagy, Clearing & Cleaning – Phase 2
Mitochondrial dysfunction is a hallmark of metabolic decline (vitality) during aging. Ref. You’re constantly replacing your old, weak, dysfunctional mito with new healthy fresh mito. The population of all the mito of a given cell constitutes your Chondriome. Like your MicroBiome, we have a healthy pool of them or an unhealthy pool, which dictates how functional they are. The average cell in your body has between 1,000-2,000 mito. Again, they turn over as they get old. They are recycled, and it’s a process medicated through a gene expression ruled by mTOR.
The mTOR pathway is a central regulator of metabolism (vitality) and physiology (function). Without getting too deep into mTOR, for now, let’s just leave it at the fact that when mTOR is inhibited, we shift into a cleaning and recycling phase where we see Autophagy and Mitophagy. Autophagy is a Latin word that translates into “self-eating.” Autophagy is the body’s way of cleaning out damaged cells in order to regenerate newer, healthier cells.
Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress.10
Remember all the types of stress? These ALL have an impact on the demand for Mitophagy to be activated through mTOR!11 So what activates mTOR and Autophagy? Fasting is the primary activator of this process! We will revisit this soon, but first, we need to talk about senescent cells. What are senescent cells, and how do they have a detrimental effect on health and life span? As they accumulate, due to poor Autophagy (which normally removes and recycles them), into fresh, healthy cells and fresh, healthy mito.
Cellular senescence is an irreversible cell-cycle arrest mechanism that acts to protect against cancer. Ref.
Basically, cellular senescence is a permanent state of sleep a cell goes into. This state is associated with a release of inflammatory products, and higher energy consumption, pulling it away from your healthy cells.12 They are zombies in the literal sense!
Fig 1
Production of pro-inflammatory cytokines and chemokines, is emerging as a common feature of senescent cells irrespective of the senescence-inducing stressor or mechanism (Fig. 1).
Cultured cells usually reach senescence within several weeks after exposure, to senescence-inducing stressors, but remain viable for months after that. Ref
This means these “zombies” will float around spewing inflammation and sucking the life out of your body, by deferring vital energy that would normally be going to healthy cells. In this study scientists found fasting reduced hearing loss through autophagy. The Antioxidative Role of Autophagy in Hearing Loss. Ref 14
So what’s the answer? How do you clear these senescence cells from the body?
It happens to be the same process involved with Autophagy and Mitophagy, where mTOR is involved. Fasting and Senolytics are the best answer to clean, clear, and recycle these “zombie” cells. This is why we stack the most powerful senolytics on the planet with a 24-hour lunch to lunch fast that can be done each week or pulsed as directed by your health care provider.
Fisetin is a must for any one looking to improve senolytic effects (effects to clear senescent cells. See this article on Fisetin here.
Lastly the Stem Cell Activation Phase! Phase 3
After the break down of the cleaning / autophagy phase the body and your inner ears are ready for growth and repair through phase 3. mTOR positively regulates cell growth and proliferation, by promoting many anabolic processes, including biosynthesis of proteins, lipids and organelles such as mitochondria. Journel (1)
Growing new mitochondria is called mitochondrial biogenesis, and mTOR activates this very powerfully!
Mitochondrial metabolism and biogenesis are both regulated by mTOR activation. (Schieke et al., 2006)
Protein is the most effective activator of phase 3. I suggest you increase your protein intake to 20 or more grams a day with a highly absorbable form of proteins. In addition to protein supplementation, I suggest your diet consist of fish, chicken and steak in 2 of the 3 meals those last 2 days in the phase 3 (or both if your only eating 2 times a day). For protein supplementation, Perfect Amino’s is a good and highly absorbable form of protein I like and is tolerable to most. 4 scoops per day will do. In addition, the specific protein that activates growth and repair is Leucine, and we have a product called StemTOR (Activates mTOR) that has a high and super absorbable way to get leucine into your blood stream. In addition to Leucine there are a few nutraceuticals that have been shown to be great activators of growth and repair.
HMB- a powerful activator of mTOR. Studies show supplementation with HMB show a significant increase in the anaerobic peak power, average power, maximum speed, post-exercise lactate concentrations, a significant increase in fat-free mass and a reduction in the fat.(3)
Rhodiola- Encourages a healthy response to physical activity and mental emotional stress, by supporting stress hormones such as cortisol, the main stress hormone. Rhodiola enhances the anabolic effects of training and exercise and minimizes the catabolic (tissue breakdown) effect of high stress hormones, like cortisol.
Bullet Points:
PHASE 1 -NAD+ Loading to Support Mitochondrial Health and Cellular Energy.
(Can be helpful leading into a fast or period of strong autophagy signaling phase).
Take NAD+Max Suppositories with both NAD+, NR and NMN. 2 suppositories per day for 2 days.
Use liposomal NAD+ products such as NADMax Ultra.
NeuroNAD+ Nasal Spray- 2 sprays each nostril 3 times a day.
PHASE 2 -Maximize Autophagy:
Fasting. Extended or intermittent fasting works at different signaling strengths. Do a 24 hour fast.
Consume senolytics like Fisetin, Quercetin and Resveratrol which can be taken as liposomal and suppository for better absorption. Take Lucitol Ultra (10ml 2 times a day) or Lucitol Suppository (1 2 times a day) for 2 days.
Exercise can promote autophagy.
Consume foods, spices and teas to promote autophagy like ginger, coffee, green tea, elderberries, turmeric, ginseng tea, garlic, chaga, reishi, pomegranate and ceylon cinnamon.
Use ozone to increase ROS to activate autophagy in the form IV ozone in the Clinic.
Maximize mTOR After a Fast.
Consume more protein. Best with shakes post fasting versus steak might be too diff to break down just after fasting. Take 20 gm of Perfect Amino’s for 2 days and consume fish, chicken or beef for 2 meals a day for 2 days.
Take supplements like Leucine, Rhodiola, HMB. StemTOR -1 /2 times a day for 2 days.
Sensory Rejuvenation Protocol
Purpose: Amplifying Regeneration to the Inner Ear.
Building back Cellular NAD+ levels for Mitochondrial support.
Assisting the Autophagy & Mitophagy signaling response using Senolytics.
Stimulating a growth phase via stem cell and Hormetic response.
Stimulating microbiome swarming and bacteria diversity post fast.
NAD+ Loading phase 1 – Day 1-2
NAD+Max as an NAD+ Loading Phase. Increase cellular energy threrfore a stronger stimulus to autophagy and ultimately better results for your fasting.
NAD+Max Suppository 2 times a days. After morning bowel movement and later in the day.
(OR)
Liposomal NAD+Max Ultra take 10 mil 2 times a day. (Substitute to suppository)
Fasting Phase 2: Senolytic & Autophagy Phase – Day 3-4
Lucitol – A powerful senolytic to activate greater Autophagy to clear out senescent cells and dysfunctional mitochondria.
Lucitol Suppository 2 times a days. After morning bowel movement and later in the day. (Substitute to suppository)
(OR)
Liposomal Lucitol Ultra – take 10 mil 2 times a day. Read here on senolytics.
Growth & Repair Phase 3 – Day 5–6
Time to stimulate stem cells, growth and repair and regeneration. This is through mTOR!
Perfect Amino’s 4 scoops per day. 5 grams per scoop. Best to take 15-30 grams a day during this phase. A diet high is protein during this phase will activates mTOR!
I recommend this protocol weekly for 3 months with a stronger 3 day fast one of the weeks each month. This fast is called a “Fast Track Fast” and is done for 3 day for each phase and the Phase 2 is done with a 3 day water fast (4 hour feeding window alternative).
Before you start this protocol, consult your health care provider and use their guidance, as this article is not meant to be medical advice.
If you are looking to be better, think clearer, have more energy, function at a higher level, and have healthier ears, these two aspects of health that lead to better and stronger Mito can’t be ignored. Restoring youthful NAD+ levels, using cellular clean up and recycling such as Autophagy and Mitophagy followed by a strong stem cell activation can be a great strategy. The Sensory Rejuvenation Protocol is easy to do and tolerated by most. The Sensory Rejuvenation Protocol for LumoMed support be done once a week for 3 months then 1 time a month for another 9 months. If you’re getting LumoMed 1 time a month, it will be best to come in for your once a month LumoMed treatment during the phase 3.
Before you start this protocol, consult your health care provider and use their guidance.
John Lieurance, ND, DC
(941) 330-8553
References
Bai et al., (2011) Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/#R2
Gomes et al., (2013) Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/#R5
Yoshino et al., (2011) Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/#R9
Zhang et al., (2016) Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/#R10
https://www.nobelprize.org/nobel_prizes/chemistry/laureates/1929/euler-chelpin-lecture.pdf
Tirumurugaan et al., (2008) Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/#R7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/
https://www.sciencedirect.com/science/article/pii/S2468501118300063
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990190/
https://en.wikipedia.org/wiki/Mitophagy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630798/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214092/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214092/#R42
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333736/
https://www.nature.com/articles/s41514-019-0040-z.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(14)00500-2
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